Villainous

Black Hat: an ancient and malevolent mastermind of unknown origin or species who runs Black Hat Org., appears in all of the ads that the company produces, and is hinted to be the source of all evil in the multiverse.
Dr. Kenning "Flug" Flugslys: a nervous, nerdy, but somewhat kind and respectful scientist who wears multiple paper bags over his head who works for Black Hat.
Demencia; Black Hat's crazed fan and assistant who wears a tracking device.

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: one of the Organization's failed experiments that cannot be killed.
Cam Bot: the one who films all of Black Hat Org.'s ads. It is a sentient camera with useful attachments, however, the make-up puff arm was removed by Black Hat when it attempted to use it on him.
Penumbra / Dr. Penelope Numan Braxton: a villainess of Arteno City.
Sunblast / Héctor Solares: the superhero of Arteno City, who acts like a bully towards Penumbra. He is also the only one who can withstand the sun's rays due to his suit.
Ringworm: a hero with ringworm (hence the name) who has the ability to generate ring bolts.
Bicep: a boxer superhero